Resumo

CONTRERAS, Ricardo R; URBINA-GUTIERREZ, Jesús  e  ARANGUREN, José Nelson. Therapeutic potential of organometallic compounds in the cancer treatment. A short review. Novasinergia [online]. 2018, vol.1, n.1, pp.14-22.  Epub 01-Jun-2021. ISSN 2631-2654.  https://doi.org/10.37135/unach.ns.001.01.02.

According to the World Health Organization (WHO), cancer is the second cause of death in the world, almost one out of every six deaths globally is due to this disease. In chemistry area, efforts are being made to better investigate anticancer compounds, and organometallic reagents offer an interesting opportunity, for a synergistic effect between the medicinal properties of the ligands and the chemical characteristics of the transition metals. In this article, we present a short review of some advances in anticancer organometallic compounds. The review indicates that small structural changes implicate large changes in anticancer activity, which generates new possibilities more specific chemotherapies, with less side-effects and economically more affordable.

Palavras-chave : Therapeutics agents; cancer; organometallic compounds; ligands; transition metals.

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