<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2631-2581</journal-id>
<journal-title><![CDATA[Revista Ecuatoriana de Neurología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ecuat Neurol]]></abbrev-journal-title>
<issn>2631-2581</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica Ecuatoriana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2631-25812021000300031</article-id>
<article-id pub-id-type="doi">10.46997/revecuatneurol30300031</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Niveles Altos De Hemoglobina Glicosilada Se Asocian A Hemorragia Intracerebral Espontánea: Estudio De Casos Y Controles]]></article-title>
<article-title xml:lang="en"><![CDATA[High Levels Of Glycated Hemoglobin Are Associated With Spontaneous Intracerebral Hemorrhage: A Case Control Study]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[Jenniffer]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[Alex]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galarza Bernita]]></surname>
<given-names><![CDATA[David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuenca]]></surname>
<given-names><![CDATA[John A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Naval de Guayaquil Servicio de Medicina Interna Departamento de Clínica]]></institution>
<addr-line><![CDATA[Guayaquil ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,The University of Texas MD Anderson Cancer Center Departamento de Cuidados Críticos ]]></institution>
<addr-line><![CDATA[Houston Texas]]></addr-line>
<country>USA</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>30</volume>
<numero>3</numero>
<fpage>31</fpage>
<lpage>37</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&amp;pid=S2631-25812021000300031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&amp;pid=S2631-25812021000300031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_pdf&amp;pid=S2631-25812021000300031&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Existe evidencia de la asociación entre valores de hemoglobina glicosilada (HbA1C) con hemorragia intracerebral espontánea (HICE). Sin embargo, los reportes en pacientes latinoamericanos son escasos.  Objetivo: Determinar si HbA1c es factor de riesgo de HICE  Métodos: Se realiza un estudio de casos y controles. Los casos fueron pacientes hospitalizados con HICE, los controles fueron pacientes diabéticos ambulatorios del mismo grupo etario. Calculamos la asociación entre factores de riesgo de HICE mediante la regresión logística.  Resultados: Se identificaron 45 casos y 45 controles. Los valores de HbA1c en el grupo con HICE (mediana 6.8%, RIQ=5.8-7.5) fueron superiores que los controles (mediana 5.8%, RIQ=5.5-6.2%; P&lt;0.001). La HbA1c fue factor de riesgo asociado con HICE (OR=2.75, 95% IC=1.41-5.41). De los pacientes con HICE, solo el 29% había recibido diagnóstico previo de diabetes. La tasa de mortalidad hospitalaria en los pacientes con HICE fue de 37.8%, siendo 15% en los pacientes con diabetes y 46% en aquellos sin diagnóstico de diabetes.  Conclusiones: Valores elevados de HbA1c se asociaron con el desarrollo de HICE. Es necesario mejorar las políticas públicas de detección temprana de diabetes ya que podrían reducir el impacto de hemorragia intracerebral espontánea en la población general.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Evidence shows that glycosylated hemoglobin (HbA1C) is associated with spontaneous intracerebral hemorrhage (ICH). However, reports in Latin-American patients are scarce.  Objective: To determine if HbA1C is a risk factor for ICH.  Methods:  A case-control study was carried out. Cases were hospitalized patients with ICH, whereas the controls were diabetic patients within the same age range. Logistics regression was calculated to identify risk factors associated with ICH.  Results: A total of 45 cases and 45 controls were included. HbA1C values were higher in the ICH group (median 6.8%, IQR=5.8-7.5) compared to the control group (median 5.8%, IQR=5.5-6.2%; P&lt;0.001). High HbA1C values were identified as a risk factor for ICH (OR=2.75, 95% CI=1.41-5.41). Among the ICH patients, barely 29% had a confirmed previous diagnosis of diabetes. The hospital mortality rate in the ICH patients was 37.8%, while mortality was 15% in the patients with diabetes and 46% in those without a previous diabetes diagnosis.  Conclusions: High HbA1C levels were associated with the development of ICH. It is paramount to improve public policies for early detection of diabetes due to the potential to reduce the impact of spontaneous intracerebral hemorrhage in the general population.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hemorragia intracerebral]]></kwd>
<kwd lng="es"><![CDATA[evento cerebrovascular]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo]]></kwd>
<kwd lng="es"><![CDATA[hemoglobina glicosilada]]></kwd>
<kwd lng="es"><![CDATA[hiperglicemia]]></kwd>
<kwd lng="es"><![CDATA[diabetes.]]></kwd>
<kwd lng="en"><![CDATA[Intracerebral hemorrhage]]></kwd>
<kwd lng="en"><![CDATA[cerebrovascular event]]></kwd>
<kwd lng="en"><![CDATA[risk factors]]></kwd>
<kwd lng="en"><![CDATA[glycosylated hemoglobin]]></kwd>
<kwd lng="en"><![CDATA[hyperglycemia]]></kwd>
<kwd lng="en"><![CDATA[diabetes.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Location-specific risk factors for intracerebral hemorrhage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jolink]]></surname>
<given-names><![CDATA[WMT]]></given-names>
</name>
<name>
<surname><![CDATA[Wiegertjes]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Rinkel]]></surname>
<given-names><![CDATA[GJE]]></given-names>
</name>
<name>
<surname><![CDATA[Algra]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[de Leeuw]]></surname>
<given-names><![CDATA[F-E]]></given-names>
</name>
<name>
<surname><![CDATA[Klijn]]></surname>
<given-names><![CDATA[CJM]]></given-names>
</name>
</person-group>
<source><![CDATA[Neurology]]></source>
<year>2020</year>
<volume>95</volume>
<numero>13</numero>
<issue>13</issue>
<page-range>e1807-18</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Enfermedades cerebrovasculares]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sieira]]></surname>
<given-names><![CDATA[PI]]></given-names>
</name>
<name>
<surname><![CDATA[Esparragosa]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Valentí]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Vila]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hemorragia cerebral. Med - Programa Form Médica Contin Acreditado]]></source>
<year>2019</year>
<volume>12</volume>
<numero>70</numero>
<issue>70</issue>
<page-range>4075-84</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Actualización en diagnóstico y tratamiento del ataque cerebrovascular isquémico agudo]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[García Alfonso]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez Reyes]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Ricaurte Fajardo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Coral Casas]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Univ Médica]]></source>
<year>2019</year>
<volume>60</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1-17</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Stroke]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Campbell]]></surname>
<given-names><![CDATA[BCV]]></given-names>
</name>
<name>
<surname><![CDATA[Khatri]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2020</year>
<volume>396</volume>
<numero>10244</numero>
<issue>10244</issue>
<page-range>129-42</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Priorities to reduce the burden of stroke in Latin American countries.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ouriques Martins]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Sacks]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Hacke]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Brainin]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[de Assis Figueiredo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Marques Pontes-Neto]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet Neurol]]></source>
<year>2019</year>
<volume>18</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>674-83</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A Retrospective Analysis of Factors Impacting Rehabilitation Outcomes in Patients With Spontaneous Intracerebral Hemorrhage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Phys Med Rehabil.]]></source>
<year>2020</year>
<volume>99</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1004-11</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Guías de actuación clínica en la hemorragia intracerebral]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodríguez-Yáñez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Castellanos]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Freijo]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[López Fernández]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Martí-Fàbregas]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Nombela]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Neurología]]></source>
<year>2013</year>
<volume>28</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>236-49</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Enfermedad Cerebrovascular en el Ecuador: Análisis de los Últimos 25 Años de Mortalidad, Realidad Actual y Recomendaciones]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moreno-Zambrano]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Santamaria]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ludena]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Barco]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vasquez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Santibanez-Vasquez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Ecuatoriana Neurol]]></source>
<year>2016</year>
<volume>25</volume>
<numero>1-3</numero>
<issue>1-3</issue>
<page-range>17-20</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[O&#8217;Donnell]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Xavier]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Chin]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Rao-Melacini]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2010</year>
<volume>376</volume>
<numero>9735</numero>
<issue>9735</issue>
<page-range>112-23</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Risk Factors of Intracerebral Hemorrhage: A Case-Control Study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sallinen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Pietilä]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Salomaa]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Strbian]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[J Stroke Cerebrovasc Dis]]></source>
<year>2020</year>
<volume>29</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>104630</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Triggering factors in non-traumatic intracerebral hemorrhage]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sallinen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Putaala]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Strbian]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[J Stroke Cerebrovasc Dis]]></source>
<year>2020</year>
<volume>29</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>104921</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Factors Associated with Inpatient Mortality after Intracerebral Hemorrhage: Updated Information from the United States Nationwide Inpatient Sample]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Javalkar]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Kuybu]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Davis]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kelley]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
</person-group>
<source><![CDATA[J Stroke Cerebrovasc Dis]]></source>
<year>2020</year>
<volume>29</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>104583</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Association between diabetes mellitus and the occurrence and outcome of intracerebral hemorrhage.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boulanger]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Poon]]></surname>
<given-names><![CDATA[MTC]]></given-names>
</name>
<name>
<surname><![CDATA[Wild]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Al-Shahi Salman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Neurology]]></source>
<year>2016</year>
<volume>87</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>870-8</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Glycemic Targets: Standards of Medical Care in Diabetes-2021]]></article-title>
<collab>Association AD. 6</collab>
<source><![CDATA[Diabetes Care.]]></source>
<year>2021</year>
<volume>44</volume>
<numero>^sSupplement 1</numero>
<issue>^sSupplement 1</issue>
<supplement>Supplement 1</supplement>
<page-range>S73-84</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Relationship Between Glycated Hemoglobin and Stroke Risk: A Systematic Review and Meta&#8208;Analysis.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mitsios]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Ekinci]]></surname>
<given-names><![CDATA[EI]]></given-names>
</name>
<name>
<surname><![CDATA[Mitsios]]></surname>
<given-names><![CDATA[GP]]></given-names>
</name>
<name>
<surname><![CDATA[Churilov]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Thijs]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[J Am Heart Assoc.]]></source>
<year>2018</year>
<volume>7</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>e007858</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hemoglobina glicada (HbAa1c). Utilidad y limitaciones en pacientes con enfermedad renal crónica | Revista de Nefrología, Diálisis y Trasplante]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[De&#8217;Marziani]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Elbert]]></surname>
<given-names><![CDATA[AE.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Nefrol Dial Traspl.]]></source>
<year>2018</year>
<volume>38</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>65-83</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[O&#8217;Donnell]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Chin]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Rangarajan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Xavier]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2016</year>
<volume>388</volume>
<numero>10046</numero>
<issue>10046</issue>
<page-range>761-75</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Complicaciones macrovasculares de la diabetes. Evaluación del riesgo cardiovascular y objetivos terapéuticos. Estrategias de prevención y tratamiento]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gimeno Orna]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Med]]></source>
<year>2016</year>
<volume>12</volume>
<numero>17</numero>
<issue>17</issue>
<page-range>947-57</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Prospective study of fasting blood glucose and intracerebral hemorrhagic risk]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Rexrode]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Gurol]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Yuan]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Hui]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2018</year>
<volume>49</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>27-33</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Association of diabetes and glycated hemoglobin with the risk of intracerebral hemorrhage: A population-based cohort study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saliba]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Barnett-Griness]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Gronich]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Molad]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Naftali]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rennert]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Diabetes Care]]></source>
<year>2019</year>
<volume>42</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>682-8</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hiperglicemia como factor de mal pronóstico del evento cerebrovascular en pacientes no diabéticos.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Macias]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
<name>
<surname><![CDATA[Tituana]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Toscano]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Med FCM-UCSG.]]></source>
<year>2011</year>
<volume>17</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>170-6</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neuroprotección no Farmacológica en el Manejo de Pacientes con Ictus Agudo]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Del Brutto]]></surname>
<given-names><![CDATA[OH]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Ecuatoriana Neurol]]></source>
<year>2003</year>
<volume>12</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1-12</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Heart Disease and Stroke Statistics-2021 Update]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Virani]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Alonso]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Aparicio]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Benjamin]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Bittencourt]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Callaway]]></surname>
<given-names><![CDATA[CW]]></given-names>
</name>
</person-group>
<source><![CDATA[Circulation]]></source>
<year>2021</year>
<volume>143</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>E254-743</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
