<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2631-2581</journal-id>
<journal-title><![CDATA[Revista Ecuatoriana de Neurología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ecuat Neurol]]></abbrev-journal-title>
<issn>2631-2581</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica Ecuatoriana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2631-25812020000100125</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Neurogénesis Y Ejercicios Físicos: Una Actualización]]></article-title>
<article-title xml:lang="en"><![CDATA[Neurogenesis And Physical Exercise: An Update]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Siteneski]]></surname>
<given-names><![CDATA[Aline]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez García]]></surname>
<given-names><![CDATA[Joyce Aylín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olescowicz]]></surname>
<given-names><![CDATA[Gislaine]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Técnica de Manabí Instituto de Investigación ]]></institution>
<addr-line><![CDATA[Portoviejo ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Técnica de Manabí Facultad de Ciencias de la Salud Carrera de Medicina]]></institution>
<addr-line><![CDATA[Portoviejo ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Federal de Santa Catarina Centro de Ciencias Biológicas Departamento de Farmacología]]></institution>
<addr-line><![CDATA[Florianópolis ]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<volume>29</volume>
<numero>1</numero>
<fpage>125</fpage>
<lpage>136</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&amp;pid=S2631-25812020000100125&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&amp;pid=S2631-25812020000100125&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_pdf&amp;pid=S2631-25812020000100125&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La neurogénesis es un mecanismo de plasticidad estructural encefálica que puede ser definido como el proceso de producción de nuevas neuronas a partir de células madres neurales o células progenitoras. Actualmente está aceptado que la neurogénesis ocurre principalmente en dos distintos nichos neurogénicos del cerebro adulto de humanos y de roedores, la zona subgranular (ZSG) en el giro dentado (GD) del hipocampo, y la zona subventricular (ZSV) en los ventrículos laterales. Es un proceso complejo que depende de diversos factores finamente regulados, lleva de cuatro a seis semanas para ser completado y puede ser regulado positiva o negativamente por factores intrínsecos o extrínsecos. Entre los principales reguladores positivos de la neurogénesis está el ejercicio físico. Varios estudios evidencian la importancia de la práctica regular de ejercicio físico para la salud general y para las funciones cognitivas. En el hipocampo estimula el aumento de la proliferación, diferenciación y sobrevivencia de neuronas, remodela la sinapsis y modifica propiedades neuronales. De esta manera, protege el deterioro cognitivo decurrente de enfermedades o del proceso natural de envejecimiento. Así, el objetivo de esta revisión es traer información sobre la neurogénesis, además, de una actualización que busca elucidar los posibles mecanismos por los cuales el ejercicio físico favorece la neurogénesis hipocampal adulta.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Neurogenesis is a brain mechanism of structural plasticity that could be defined as a process of production of new neurons from neural stem cells or progenitor cells. Currently is accepted that neurogenesis occurs mainly in two different neurogenic niches of humans and rodents&#8217; adult brain, the granular zone (ZSG) in the dentate gyrus (GD) of the hippocampus, and the subventricular zone (ZSV) in the lateral ventricles. It is a complex process that depends on various factors being finely regulated, takes four to six weeks to complete and could be regulated positively or negatively by intrinsic or extrinsic factors. Among the main positive regulators of neurogenesis is the physical exercise. Several studies showed the importance of regular practice of physical exercise for general health and cognitive functions. In the hippocampus, it is able to increase the cellular proliferation, differentiation and neuronal survival. In addition, physical exercise acts in synapses remodeling and modifying neuronal properties, protecting cognitive deterioration due to diseases or the natural aging process. Thus, the objective of this review is to bring information on neurogenesis and an update that seeks to elucidate the possible mechanisms by which physical exercise favors adult hippocampal neurogenesis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Neurogénesis]]></kwd>
<kwd lng="es"><![CDATA[Ejercicio físico]]></kwd>
<kwd lng="es"><![CDATA[Neuroplasticidad hipocampal]]></kwd>
<kwd lng="es"><![CDATA[Giro Dentado.]]></kwd>
<kwd lng="en"><![CDATA[Neurogenesis]]></kwd>
<kwd lng="en"><![CDATA[Physical exercise]]></kwd>
<kwd lng="en"><![CDATA[Hippocampal neuroplasticity]]></kwd>
<kwd lng="en"><![CDATA[Dentate Gyrus.]]></kwd>
</kwd-group>
</article-meta>
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