<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2631-2581</journal-id>
<journal-title><![CDATA[Revista Ecuatoriana de Neurología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ecuat Neurol]]></abbrev-journal-title>
<issn>2631-2581</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica Ecuatoriana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2631-25812019000100056</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La Actividad Embrionaria Espontánea De Las Redes Neuronales Y Su Función En La Maduración Sináptica]]></article-title>
<article-title xml:lang="en"><![CDATA[Embryonic Spontaneous Network Activity And Its Role On Synaptic Development]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Islas]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Bereguiain]]></surname>
<given-names><![CDATA[Miguel Angel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Emory University School of Medicina  ]]></institution>
<addr-line><![CDATA[Atlanta Georgia]]></addr-line>
<country>USA</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de las Américas Facultad de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>28</volume>
<numero>1</numero>
<fpage>56</fpage>
<lpage>62</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&amp;pid=S2631-25812019000100056&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&amp;pid=S2631-25812019000100056&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_pdf&amp;pid=S2631-25812019000100056&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Los circuitos neuronales embrionarios poseen propiedades transitorias que originan una forma especial de actividad eléctrica conocida como Actividad Embrionaria Espontánea (AEE). La AEE se manifiesta tan pronto como las conexiones sinápticas se establecen, y consiste en descargas de potenciales de acción que ocurren sincrónicamente en la mayoría de las neuronas que componen el circuito, seguidas por largos periodos silentes en donde la excitabilidad se recupera paulatinamente para poder generar un nuevo episodio. Este tipo de actividad neuronal permite un alto grado de sincronización entre las neuronas de los circuitos en desarrollo y contribuye a la construcción y maduración sinápticas. Diversas regiones del sistema nervioso embrionario de los vertebrados presentan AEE ya que su manifestación depende de propiedades que comparten la mayoría de las redes neuronales en desarrollo: una conectividad intercelular redundante y el hecho de que el neurotransmisor ácido gamma-aminobutírico (GABA) es excitatorio durante el desarrollo embrionario (En el sistema nervioso adulto GABA es inhibitorio). En esta revisión discutimos la idea de que la presencia de AEE podría contribuir a establecer la fuerza sináptica de las sinapsis glutamatérgicas y GABAérgicas en un momento en el que ambas comparten una naturaleza excitadora, utilizando un mismo mecanismo de plasticidad sináptica conocido como plasticidad homeostática.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Embrionic neural networks exibit a temporary special form of electrical activity known as Spontaneous Network Activity (SNA). SNA occurs as soon as synaptic conections are stablished and consists on synchronized action potential firing for most of the neurons on the network, followed by long silents periods where network excitability is gradually recovered till a new SNA episode can happen. This kind of neural activity allows a high level of synchronization among neurons on developing networks, contributing to synaptic connection and maturation. SNA has been described in several regions of the developing nervous system due to conserved properties among developing neural networks: redundant intercellular connectivity and the fact that the neurotransmitter gamma-aminobutiric acid (GABA) is excitatory during early embryonic development (GABA is inhibitory in the adult nervous system).In this review we discuss the hypothesis that SNA contributes to synaptic strenght for glutamatergic and gabaergic synapsis while both of them are excitatory, by using the same synaptic plasticity mechanism known as homeostatic plasticity.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Actividad embrionaria espontánea]]></kwd>
<kwd lng="es"><![CDATA[plasticidad homeostática]]></kwd>
<kwd lng="es"><![CDATA[desarrollo embrionario.]]></kwd>
<kwd lng="en"><![CDATA[Spontaneous network activity]]></kwd>
<kwd lng="en"><![CDATA[homeostatic plasticity]]></kwd>
<kwd lng="en"><![CDATA[embryonic development.]]></kwd>
</kwd-group>
</article-meta>
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