<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2631-2581</journal-id>
<journal-title><![CDATA[Revista Ecuatoriana de Neurología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ecuat Neurol]]></abbrev-journal-title>
<issn>2631-2581</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica Ecuatoriana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2631-25812018000100051</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Retardo En La Llegada De Pacientes Con Ictus Isquémico A Un Hospital Terciario De Ecuador.]]></article-title>
<article-title xml:lang="en"><![CDATA[Delay In The Arrival Of Ischemic Stroke Patients At A Tertiary Hospital In Ecuador.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Scherle]]></surname>
<given-names><![CDATA[Claudio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivero]]></surname>
<given-names><![CDATA[Danny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Di Capua]]></surname>
<given-names><![CDATA[Daniella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maldonado]]></surname>
<given-names><![CDATA[Nelson]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad San Francisco de Quito USFQ Hospital de Especialidades Eugenio Espejo Servicio de Neurología]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Especialidades Eugenio Espejo Servicio de Neurología ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad San Francisco de Quito USFQ  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>27</volume>
<numero>1</numero>
<fpage>51</fpage>
<lpage>55</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&amp;pid=S2631-25812018000100051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&amp;pid=S2631-25812018000100051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_pdf&amp;pid=S2631-25812018000100051&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: El tratamiento del ictus isquémico con trombolisis farmacológica en el entorno de una unidad de ictus se asocia a una mejor recuperación. El objetivo de este estudio es identificar variables que pudieran relacionarse con un retardo en la llegada al hospital.  Métodos: Se realizó un estudio prospectivo, longitudinal, en los pacientes con diagnóstico de ictus isquémico que ingresaron en la Unidad de Ictus del Hospital de especialidades Eugenio Espejo de la ciudad de Quito, Ecuador, en el periodo comprendido entre noviembre de 2016 a julio de 2017. Se compararon los pacientes que fueron tratados con r-Tpa con los que llegaron después de las 4,5 horas.  Resultados: Se estudiaron un total de 61 pacientes: 51 de ellos arribaron al hospital después de las 4,5 horas, y 10 (16,4 %) fueron sometidos a trombolisis en periodo de ventana terapéutica. Ninguna de las variables sociodemográficas y clínicas excepto el antecedente de fibrilación auricular se relacionó con el arribo precoz. En el grupo que recibió r-Tpa el porcentaje de pacientes que buscó atención médica en el hospital como primera opción fue significativamente mayor respecto a los que llegaron después del periodo de ventana (90 vs 49 %, p 0,0170). El mayor impacto de la remisión precoz y la trombolisis fue sobre la diferencia de puntaje entre la evaluación inicial y al alta en la escala del NIHSS.  Conclusiones: Los resultados apuntan a que existe desconocimiento acerca del ictus y qué conducta asumir. El tratamiento con r-Tpa demuestra beneficios en nuestro medio.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  In an Stroke unit, the ischemic stroke treatment with a pharmacological thrombolysis is associated with a better recovery. The aim of this study is to identify the variables having a significant impact in the delay of the arrival of patients at a tertiary hospital.  Methods:  A prospective and longitudinal study was undertaken in patients with an ischemic stroke diagnosis, who were admitted to the Stroke Unit of Eugenio Espejo Hospital of Quito city in Ecuador in the time period from November 2016 to July 2017. Patients treated with r-Tpa were compared to those who arrived 4,5 hours later.  Results:  A total of 61 patients were analyzed: of those, 51 arrived 4,5 hours after first symptoms at the hospital, and 10 (16,4%) were thrombolysed in the period of therapeutic window. None of the social, demographic and clinical variables were related to the early arrival, except the history of an atrial fibrillation. In the group of patients who received r-Tpa, a significantly higher percent sought for medical care as a first option compared with those arriving after the 4,5 hours (90 vs 49%, p 0,0170). The greatest impact of the early referral and the thrombolysis concerned the difference of score between the initial medical evaluation and the hospital discharge in the NIHSS scale.  Conclusions:  The results of this study point out to the unawareness of the stroke and the behavior to follow. The r-Tpa treatment shows clear benefits to the patients in our environment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedad cerebrovascular]]></kwd>
<kwd lng="es"><![CDATA[ictus isquémico]]></kwd>
<kwd lng="es"><![CDATA[infarto cerebral]]></kwd>
<kwd lng="es"><![CDATA[trombolisis]]></kwd>
<kwd lng="es"><![CDATA[hospital terciario]]></kwd>
<kwd lng="es"><![CDATA[llegada temprana]]></kwd>
<kwd lng="en"><![CDATA[Cerebrovascular disease]]></kwd>
<kwd lng="en"><![CDATA[Ischemic stroke]]></kwd>
<kwd lng="en"><![CDATA[Cerebral infarction]]></kwd>
<kwd lng="en"><![CDATA[Thrombolysis. Tertiary hospital]]></kwd>
<kwd lng="en"><![CDATA[Early arrival]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Global stroke statistics.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thrift]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
<name>
<surname><![CDATA[Thayabaranathan]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Howard]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Howard]]></surname>
<given-names><![CDATA[VJ]]></given-names>
</name>
<name>
<surname><![CDATA[Rothwell]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Feigin]]></surname>
<given-names><![CDATA[VL]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Stroke]]></source>
<year>2017</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>13-32</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Enfermedad Cerebrovascular en el Ecuador: Análisis de los Últimos 25 Años de Mortalidad, Realidad Actual y Recomendaciones.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moreno-Zambrano]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Santamaría]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ludeña]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Barco]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vásquez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Santibáñez-Vásquez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Ecuat Neurol]]></source>
<year>2016</year>
<volume>25</volume>
<numero>1-3</numero>
<issue>1-3</issue>
<page-range>17-20</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Activador del Plasminógeno tisular, realidad actual. Estudio transversal retrospectivo entre los años 2007-2009 en el Hospital Regional Dr. Teodoro Maldonado Carbo.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Santibáñez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bjerre]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Santibáñez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Bernabé]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Santibáñez-Vásquez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Ecuat Neurol]]></source>
<year>2011</year>
<volume>20</volume>
<numero>1-3</numero>
<issue>1-3</issue>
<page-range>20-6</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Conocimiento y actitud de la población general frente al ictus.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Amarilla]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Güesta]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Leno]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Portilla]]></surname>
<given-names><![CDATA[JC.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Cient Soc Esp Enferm Neurol.]]></source>
<year>2015</year>
<volume>41</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>15-21</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Public perception of stroke in Spain.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Segura]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Vega]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rubio]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cerebrovasc Dis.]]></source>
<year>2003</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>21-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical interpretation and use of stroke scales.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kasner]]></surname>
<given-names><![CDATA[SE.]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet Neurol.]]></source>
<year>2006</year>
<volume>5</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>603-12</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hacke]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Kaste]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bluhmki]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Brozman]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Dávalos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Guidetti]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med.]]></source>
<year>2008</year>
<volume>359</volume>
<numero>13</numero>
<issue>13</issue>
<page-range>1317-29</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Guidelines for the early management of Patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jauch]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
<name>
<surname><![CDATA[Saver]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Adams]]></surname>
<given-names><![CDATA[HP]]></given-names>
</name>
<name>
<surname><![CDATA[Bruno]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Connors]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Demaerschalk]]></surname>
<given-names><![CDATA[BM]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2013</year>
<volume>44</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>870-947</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[TOAST classification of subtypes of ischaemic stroke: diagnostic and therapeutic procedures in stroke. A four-year observation.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Paradowski]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Maciejak]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cerebrovasc Dis.]]></source>
<year>2005</year>
<volume>20</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>319-24</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Banks]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Marotta]]></surname>
<given-names><![CDATA[CA.]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2007</year>
<volume>38</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1091-6</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Classification and natural history of clinically identificable subtypes of cerebral infarction.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bamford]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sandercock]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Dennis]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Burn]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Warlow]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>1991</year>
<volume>337</volume>
<numero>8756</numero>
<issue>8756</issue>
<page-range>1521-6</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Tissue plasminogen activator for acute ischemic stroke.]]></article-title>
<collab>The National Institute of Neurological Disorders and Stroke r-tPA Stroke Study Group.</collab>
<source><![CDATA[N Engl J Med.]]></source>
<year>1995</year>
<volume>333</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>1581-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[La Unidad de Ictus modifica las características de la atención del ictus en un hospital terciario.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Scherle]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Roselló]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Cubana Neurol Neurocir.]]></source>
<year>2011</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>3-6</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goyal]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Menon]]></surname>
<given-names><![CDATA[BK]]></given-names>
</name>
<name>
<surname><![CDATA[van Zwam]]></surname>
<given-names><![CDATA[WH]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2016</year>
<volume>387</volume>
<numero>10029</numero>
<issue>10029</issue>
<page-range>1723-31</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS and NINDS rt-PA stroke trials.]]></article-title>
<collab>The ATLANTIS, ECASS and NINDS rt-PA Study Group Investigators.</collab>
<source><![CDATA[Lancet]]></source>
<year>2004</year>
<volume>363</volume>
<numero>9411</numero>
<issue>9411</issue>
<page-range>768-74</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Acute Stroke Treatment in the Community: Improving Our Performance and Expanding Our Options.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Russman]]></surname>
<given-names><![CDATA[AN]]></given-names>
</name>
<name>
<surname><![CDATA[Katzan]]></surname>
<given-names><![CDATA[IL.]]></given-names>
</name>
</person-group>
<source><![CDATA[Seminars in neurology]]></source>
<year>2005</year>
<volume>25</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>337-44</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Knowledge of risk factors, and warning signs of stroke: a systematic review from a gender perspective.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stroebele]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Müller-Riemenschneider]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Nolte]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Müller-Nordhorn]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bockelbrink]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Willich]]></surname>
<given-names><![CDATA[SN.]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Stroke]]></source>
<year>2011</year>
<volume>6</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>60-6</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Prioritizing interventions to improve rates of thrombolysis for ischemic stroke.]]></article-title>
<collab>California Acute Stroke Pilot Registry (CASPR) Investigators.</collab>
<source><![CDATA[Neurology]]></source>
<year>2005</year>
<volume>64</volume>
<page-range>654-9</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[El acceso precoz a centros de referencia de ictus ofrece beneficio clínico: el Código Ictus.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez de la Ossa-Herrero]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Neurol.]]></source>
<year>2008</year>
<volume>47</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>427-33</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Canadian Stroke Best Practice Recommendations: Managing transitions of care following Stroke, Guidelines Update 2016]]></article-title>
<collab>Heart and Stroke Foundation Canadian Stroke Best Practice Committees.</collab>
<source><![CDATA[Int J Stroke.]]></source>
<year>2016</year>
<volume>11</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>807-22</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The Cost-Effectiveness of a Stroke Unit in Providing Enhanced Patient Outcomes in an Australian Teaching Hospital.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhai]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gardiner]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Neeman]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Gawarikar]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[J Stroke Cerebrovasc Dis.]]></source>
<year>2017</year>
<volume>S1052-3057</volume>
<numero>17</numero>
<issue>17</issue>
<page-range>30255-0</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cost-effectiveness of tissue-type plasminogen activator in the 3- to 4.5-hour time window for acute ischemic stroke.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tung]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
<name>
<surname><![CDATA[Win]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Lansberg]]></surname>
<given-names><![CDATA[MG.]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2011</year>
<volume>42</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2257-62</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cost-effectiveness of recombinant tissue-type plasminogen activator within 3 hours of acute ischemic stroke: current evidence.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boudreau]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[Guzauskas]]></surname>
<given-names><![CDATA[GF]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Lalla]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Tayama]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fagan]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2014</year>
<volume>45</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>3032-9</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
