<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2631-2581</journal-id>
<journal-title><![CDATA[Revista Ecuatoriana de Neurología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ecuat Neurol]]></abbrev-journal-title>
<issn>2631-2581</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica Ecuatoriana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2631-25812018000100016</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mortalidad por enfermedades cerebrovasculares en Ecuador 2001- 2015: Estudio de tendencias, aplicación del modelo de regresión joinpoint.]]></article-title>
<article-title xml:lang="en"><![CDATA[Mortality due to cerebrovascular diseases in Ecuador 2001- 2015: a trend study, application of the joinpoint regression model.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez-González]]></surname>
<given-names><![CDATA[Solange]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duplat]]></surname>
<given-names><![CDATA[Aglae]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Simancas]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Tecnológica Equinoccial Facultad de Ciencias de la Salud Eugenio Espejo Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC)]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Tecnológica Equinoccial Facultad de Ciencias de la Salud Eugenio Espejo ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>27</volume>
<numero>1</numero>
<fpage>16</fpage>
<lpage>22</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&amp;pid=S2631-25812018000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&amp;pid=S2631-25812018000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_pdf&amp;pid=S2631-25812018000100016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivos: Analizar la tendencia de mortalidad por enfermedades cerebrovasculares en el Ecuador e identificar la presencia de cambios en la tendencia temporal empleando el modelo de regresión joinpoint.  Materiales y métodos: Se llevó a cabo un estudio ecológico mixto. Se calcularon las tasas de mortalidad estandarizadas por edad según sexo y provincias para los últimos 15 años (2001 a 2015) en el Ecuador. Se utilizó un análisis de regresión joinpoint (puntos de cambio) para el análisis de las tendencias.  Resultados: Desde 2001 hasta 2015 se registraron 48.621 defunciones por enfermedades cerebrovasculares en el Ecuador. En el análisis de regresión joinpoint, las tasas ajustadas por edad en los hombres descendieron de 71,4 a 59,5 defunciones por cada 100.000 habitantes, con un descenso anual de 1,51 % (p&lt;0,00), en las mujeres de 61,2 a 55,5 defunciones por cada 100.000 habitantes con un descenso anual de 1,11 % (p&lt;0,00). En las tasas de mortalidad específicas por grupo de edad, en el grupo de &#8805;80 años no se observó cambios estadísticamente significativos.  Conclusiones: La mortalidad por enfermedades cerebrovasculares ha disminuido en el Ecuador en los últimos 15 años. Su tendencia descendente se observó en casi todos los grupos de edad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Objective: To analyze the mortality trend for cerebrovascular diseases in Ecuador and to identify the presence of changes in the temporal trend using the joinpoint regression model.  Materials and Methods: A mixed ecological study was carried out. Standardized mortality rates for the last 15 years (2001 to 2015) in Ecuador were calculated and stratified by age, sex, and provinces. A joinpoint regression analysis was used for analysis of trends.  Results: From 2001 to 2015, there were 48,621 deaths from cerebrovascular diseases in Ecuador. In the joinpoint regression analysis, age-adjusted rates in men declined from 71.4 to 59.5 deaths per 100,000 population, with an annual decline of 1.51% (p &lt;0.05) in females from 61.2 to 55.5 deaths per 100,000 population, with an annual decrease of 1.11% (p &lt;0.05). In the analysis by provinces, Sucumbíos presented a growing trend of 3.17% per year (p &lt;0.05).  Conclusions: Mortality from cerebrovascular disease has declined in Ecuador in the last 15 years. The downward trend was observed in almost all age demographics.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Accidente Cerebrovascular]]></kwd>
<kwd lng="es"><![CDATA[Mortalidad]]></kwd>
<kwd lng="es"><![CDATA[Análisis de Regresión]]></kwd>
<kwd lng="es"><![CDATA[Tendencias (fuente: DeCS BIREME).]]></kwd>
<kwd lng="en"><![CDATA[Cerebrovascular diseases]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="en"><![CDATA[Regression Analysis]]></kwd>
<kwd lng="en"><![CDATA[Trends (source: MeSH NLM).]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016.]]></article-title>
<collab>GBD 2016 Mortality and Causes of Death Collaborators.</collab>
<source><![CDATA[The Lancet.]]></source>
<year>2017</year>
<volume>390</volume>
<page-range>1151-210</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: Quantifying the epidemiological transition.]]></article-title>
<collab>GBD 2013 DALYs and HALE Collaborators</collab>
<source><![CDATA[Lancet]]></source>
<year>2015</year>
<volume>386</volume>
<page-range>2145-91</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Heart disease and stroke statistics-2017 update: a report from the American Heart Association.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Benjamin]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Blaha]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Chiuve]]></surname>
<given-names><![CDATA[SE]]></given-names>
</name>
</person-group>
<source><![CDATA[Circulation]]></source>
<year>2017</year>
<volume>135</volume>
<page-range>146-603.</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Global, regional, and national age-sex specific all-cause and cause specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study2013.]]></article-title>
<collab>GBD 2013 Mortality and Causes of Death Collaborators.</collab>
<source><![CDATA[Lancet]]></source>
<year>2015</year>
<volume>385</volume>
<page-range>117 -71.3</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Premature mortality from cardiovascular disease in the Americas - will the goal of a decline of "25% by 2025" be met?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ordunez]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Prieto-Lara]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Pinheiro Gawryszewski]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS One.]]></source>
<year>2015</year>
<volume>10</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>e0141685</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comparison of trends in mortality from coronary heart and cerebrovascular diseases in north and South America: 1980 to 2013.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pagan]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Chatenoud]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Bosetti]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Levi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Malvezzi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[La Vecchia]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Negri]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bertuccio]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Cardiol.]]></source>
<year>2017</year>
<volume>119</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>862-71</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="">
<collab>Instituto Nacional de Estadísticas y Censos.</collab>
<source><![CDATA[Principales causas de mortalidad 2014: INEC [Internet].]]></source>
<year>2014</year>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="">
<collab>Ministerio de Salud Pública.</collab>
<source><![CDATA[Datos esenciales de salud: Una mirada a la década 2000-2010: MSP [Internet].]]></source>
<year>2010</year>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="confpro">
<collab>United Nations. General Assembly.</collab>
<source><![CDATA[Disponible en: http://daccess-dds-ny.un.org/ doc/UNDOC/LTD/N11/497/77/PDF/N1149777.pdf?OpenElement.]]></source>
<year>2011</year>
<conf-name><![CDATA[ Political Declarat ion of the High-level Meeting of the General Assembly on the Prevention and Control of Noncommunicable Diseases., A/66/L.1.]]></conf-name>
<conf-date>2011</conf-date>
<conf-loc>New York </conf-loc>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="">
<collab>Instituto Nacional de Estadística y Censos.</collab>
<source><![CDATA[Defunciones Generales y Fetales- Bases de Datos 2003-2013: INEC [Internet].]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="">
<collab>Instituto Nacional de Estadística y Censos.</collab>
<source><![CDATA[Proyecciones Poblacionales: INEC [Internet].]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jensen]]></surname>
<given-names><![CDATA[OM]]></given-names>
</name>
<name>
<surname><![CDATA[Parkin]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[McLennan]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Muir]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
<name>
<surname><![CDATA[Skeet]]></surname>
<given-names><![CDATA[RG.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer Registration principles and methods.]]></source>
<year>1995</year>
<publisher-loc><![CDATA[Génova: Lyon; ]]></publisher-loc>
<publisher-name><![CDATA[IARC Scientific Publications.]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Permutation test for joinpoint regression with applications to cancer rates.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Fay]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
<name>
<surname><![CDATA[Feuer]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Midthune]]></surname>
<given-names><![CDATA[DN.]]></given-names>
</name>
</person-group>
<source><![CDATA[Statist Med.]]></source>
<year>2000</year>
<volume>19</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>335-351. 188</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The decline in stroke mortality]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kunst]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Amiri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Janssen]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2011</year>
<volume>42</volume>
<page-range>2126-30</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Global and regional burden of strokeduring 1990-2010: Findings from the Global Burden of DiseaseStudy 2010.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Feigin]]></surname>
<given-names><![CDATA[VL]]></given-names>
</name>
<name>
<surname><![CDATA[Forouzanfar]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Krishnamurthi]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Mensah]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Con-nor]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bennett]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2014</year>
<volume>383</volume>
<page-range>245-55.10</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Worldwide stroke incidence and early case fatality reported in 56 population-based studies: A systematic review.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Feigin]]></surname>
<given-names><![CDATA[VL]]></given-names>
</name>
<name>
<surname><![CDATA[Lawes]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Bennett]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Barker-Collo]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Parag]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet Neu-rol.]]></source>
<year>2009</year>
<volume>8</volume>
<page-range>355-69.25</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effect of measurement on sex difference in stroke mortality.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sheikh]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Bullock]]></surname>
<given-names><![CDATA[CM.]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2007</year>
<volume>38</volume>
<page-range>1085-7</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="">
<collab>Ministerio de Salud Pública</collab>
<source><![CDATA[Ministerio de Salud continuamente emprende acciones para prevenir la hipertensión arterial. [Internet]]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[O&#8217;Donnell]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Chin]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Rangarajan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet]]></source>
<year>2016</year>
<volume>388</volume>
<page-range>761-75</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Factores asociados a la demora del tratamiento hospitalario de los pacientes con enfermedad cerebrovascular aguda.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kawano-Castillo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Chuquilín-Arista]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Tipismana- Barbarán]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Neurol]]></source>
<year>2007</year>
<volume>44</volume>
<numero>05</numero>
<issue>05</issue>
<page-range>264-8</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="">
<collab>Ministerio del Deporte.</collab>
<source><![CDATA[Muévete Ecuador iniciará en Cuenca. [Internet]]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="">
<collab>Ministerio de Salud Pública.</collab>
<source><![CDATA[Proyecto emblemático. Obtenido de &#8220;Fortalecimiento de la Red de Servicios de Salud y Mejoramiento de la Calidad&#8221;. [Internet]]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Asia Pacific Cohort Studies Collaboration. Smoking and elevated blood pressure are the most important risk factors for subarachnoid hemorrhage in the Asia-Pacific region: an overview of 26 cohorts involving 306,620 participants.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Feigin]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2005</year>
<volume>36</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1360-5.17.</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="">
<collab>Centers for Disease Control and Prevention</collab>
<source><![CDATA[The health consequences of smoking: a report of the Surgeon General.]]></source>
<year>2004</year>
<publisher-loc><![CDATA[Washington, DC ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="confpro">
<collab>World Health Organization</collab>
<source><![CDATA[World Health Organization]]></source>
<year>2015</year>
<conf-name><![CDATA[ WHO global report: mortality attributable to tobacco.]]></conf-name>
<conf-date>2015</conf-date>
<conf-loc>Geneva </conf-loc>
</nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="">
<collab>Ministerio de Salud.</collab>
<source><![CDATA[Ministerio de Salud promueve ambientes no contaminados con humo de tabaco. [Internet]]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Trends in mortality from stroke in Austria, 1980-2008.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bajaj]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Schernhammer]]></surname>
<given-names><![CDATA[ES]]></given-names>
</name>
<name>
<surname><![CDATA[Haldinger]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Walhor]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Wien. Klin. Wochenschr.]]></source>
<year>2010</year>
<volume>122</volume>
<page-range>346-53</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Stroke Outcome Research Canada (SORCan) Working Group. Stroke Outcome in Those Over 80.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saposnik]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Cote]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Phillips]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gubitz]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Bayer]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Minuk]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Black]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2008</year>
<volume>39</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2310-7</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Socioeconomic and lifestyle factors associated with chronic conditions among older adults in Ecuador.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guevara]]></surname>
<given-names><![CDATA[PE]]></given-names>
</name>
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[FCD.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Panam Salud Publica.]]></source>
<year>2015</year>
<volume>38</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>226-32</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Morbilidad por enfermedad cerebrovascular en España: incidencia y prevalencia.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez-Sempere]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Neurol.]]></source>
<year>1999</year>
<volume>29</volume>
<page-range>879-81.19</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Epidemiological studies and the prevention of stroke.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bonita]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cerebrovasc Dis.]]></source>
<year>1994</year>
<volume>4</volume>
<numero>Suppl 1</numero>
<issue>Suppl 1</issue>
<page-range>2-10.18</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; Council on Functional Genomics and Translational Biology. Factors Influencing the Decline in Stroke Mortality: a statement from the American Heart Association/American Stroke Association.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lackland]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Roccella]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Deutsch]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>2014</year>
<volume>45</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>315-53</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Stroke recurrence: predictors, severity, and prognosis. The Copenhagen Stroke Study.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jorgensen]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
<name>
<surname><![CDATA[Nakayama]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Reith]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Raaschou]]></surname>
<given-names><![CDATA[HO]]></given-names>
</name>
<name>
<surname><![CDATA[Olsen]]></surname>
<given-names><![CDATA[TS.]]></given-names>
</name>
</person-group>
<source><![CDATA[Neurology]]></source>
<year>1997</year>
<volume>48</volume>
<page-range>891-5</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Epidemiology of recurrent cerebral infarction: a Medicare claims-based comparison of first and recurrent strokes on 2-year survival and cost.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Samsa]]></surname>
<given-names><![CDATA[GP]]></given-names>
</name>
<name>
<surname><![CDATA[Bian]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lipscomb]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Matchar]]></surname>
<given-names><![CDATA[DB.]]></given-names>
</name>
</person-group>
<source><![CDATA[Stroke]]></source>
<year>1999</year>
<volume>30</volume>
<page-range>338-49</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Declining Stroke and Vascular Event Recurrence Rates in secondary prevention trials over the past 50 years and consequences for current trial design.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hong]]></surname>
<given-names><![CDATA[KS]]></given-names>
</name>
<name>
<surname><![CDATA[Yegiaian]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Saver]]></surname>
<given-names><![CDATA[JL.]]></given-names>
</name>
</person-group>
<source><![CDATA[Circulation]]></source>
<year>2011</year>
<volume>123</volume>
<numero>19</numero>
<issue>19</issue>
<page-range>2111-9</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
