<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2631-2581</journal-id>
<journal-title><![CDATA[Revista Ecuatoriana de Neurología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ecuat Neurol]]></abbrev-journal-title>
<issn>2631-2581</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica Ecuatoriana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2631-25812022000200052</article-id>
<article-id pub-id-type="doi">10.46997/revecuatneurol31200052</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hipernatremia Como Factor Pronóstico De Mortalidad En Trauma Encefalocraneano Severo]]></article-title>
<article-title xml:lang="en"><![CDATA[Hypernatremia As A Prognostic Factor Of Mortality In Patients With Severe Traumatic Brain Injury]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vásquez-Tirado]]></surname>
<given-names><![CDATA[Gustavo Adolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Segura-Plasencia]]></surname>
<given-names><![CDATA[Niler Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuadra Campos]]></surname>
<given-names><![CDATA[María del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arbayza-Ávalos]]></surname>
<given-names><![CDATA[Yessenia Katherin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quispe-Castañeda]]></surname>
<given-names><![CDATA[Claudia Vanessa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Rodríguez]]></surname>
<given-names><![CDATA[Lissett Jeanette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meregildo-Rodriguez]]></surname>
<given-names><![CDATA[Edinson Dante]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Privada Antenor Orrego Escuela de Medicina ]]></institution>
<addr-line><![CDATA[Trujillo ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad César Vallejo Escuela de Medicina ]]></institution>
<addr-line><![CDATA[Trujillo ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<volume>31</volume>
<numero>2</numero>
<fpage>52</fpage>
<lpage>58</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&amp;pid=S2631-25812022000200052&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&amp;pid=S2631-25812022000200052&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_pdf&amp;pid=S2631-25812022000200052&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El trauma craneoencefálico severo es una patología frecuente, conlleva una morbimortalidad no despreciable. La hipernatremia podría considerarse un factor asociado a mal pronóstico con el fin de optimizar la terapéutica en el grupo de pacientes de alto riesgo. Se determinó si la hipernatremia es un factor pronóstico de mortalidad en pacientes con trauma craneoencefálico en un hospital público que es centro de referencia local en trauma.  Material y Métodos:  Se realizó muestreo no probabilístico de pacientes con trauma encefalocraneano severo, adultos, ambos sexos de la Unidad de Cuidados Intensivos del Hospital Regional Docente de Trujillo, Perú en el periodo del 2015-2018.  Resultados:  La mortalidad en el grupo con y sin hipernatremia fue de 38% y 6% respectivamente (p=0,001). La diferencia de medias de la natremia entre el grupo con y sin mortalidad fue de 21,86 (IC 95% 18,2-25,5) (p=0,000). En el análisis multivariado encontramos a la hipernatremia con OR ajustado de 16,73 (IC 95% 1,96-142,82) (p=0,01). La curva ROC mostró un rendimiento adecuado para predecir la mortalidad, con un AUC de 0,878 (IC 95% 0,77-0,97) (p=0,000).  Conclusión:  La hipernatremia es un factor pronóstico de mortalidad en pacientes con trauma encefalocraneano severo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  A severe traumatic brain injury is a frequent pathology, it implies a non-negligible morbidity and mortality. Hypernatremia could be considered a factor associated with poor prognosis in order to optimize treatment in the group of high-risk patients. We aim to determine if hypernatremia is a prognostic factor of mortality in patients with severe traumatic brain injury in a public hospital which is a local reference center in trauma.  Material and Methods:  We performed a non-probabilistic sampling of adult patients of both sexes with severe traumatic brain injury from the Intensive Care Unit of the Hospital Regional Docente de Trujillo, Perú during the 2015-2018 period.  Results:  Mortality in the group with and without hypernatremia was 38% and 6% respectively (p=0.001). The difference in natremia mean values between the group with and without mortality was 21,86 (95% CI 18.2-25.5) (p=0.000). In the multivariate analysis, we found hypernatremia with adjusted OR of 16.73 (95% CI 1.96-142.82) (p=0.01). The ROC curve showed adequate performance to predict mortality, with an AUC 0.878 (95% CI 0.77-0.97) (p=0.00).  Conclusion:  Hypernatremia is a prognostic factor of mortality in patients with severe traumatic brain injury.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hipernatremia]]></kwd>
<kwd lng="es"><![CDATA[trauma encefalocraneano severo]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="en"><![CDATA[Hypernatremia]]></kwd>
<kwd lng="en"><![CDATA[severe traumatic brain injury]]></kwd>
<kwd lng="en"><![CDATA[mortality.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Past, Present and Future of Traumatic Brain Injury Research]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hawryluk]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Bullock]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Neurosurg Clin N Am]]></source>
<year>2016</year>
<volume>27</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>375-96</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Traumatic Brain Injury Epidemiology in Brazil]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[de Almeida]]></surname>
<given-names><![CDATA[CER]]></given-names>
</name>
<name>
<surname><![CDATA[de Sousa Filho]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Dourado]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Gontijo]]></surname>
<given-names><![CDATA[PAM]]></given-names>
</name>
<name>
<surname><![CDATA[Dellaretti]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[BS.]]></given-names>
</name>
</person-group>
<source><![CDATA[World Neurosurg]]></source>
<year>2016</year>
<volume>87</volume>
<page-range>540-7</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Epidemiology of traumatic brain injuries in Europe: a cross-sectional analysis.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Majdan]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Plancikova]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Brazinova]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rusnak]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Nieboer]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Lancet Public Health]]></source>
<year>2016</year>
<volume>1</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>76-84</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="book">
<article-title xml:lang=""><![CDATA[Epidemiology of traumatic brain injury.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Faul]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Coronado]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<source><![CDATA[rafman J, Salazar M editores. Handbook of Clinical Neurology.]]></source>
<year>2015</year>
<volume>127</volume>
<edition>3a</edition>
<page-range>3-13</page-range><publisher-loc><![CDATA[Estados Unidos ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Epidemiological profile of craniocerebral injuries in the Federal District in 1991]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Masini]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Bras Neurocir]]></source>
<year>1991</year>
<volume>5</volume>
<page-range>61-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cerebral Edema in Traumatic Brain Injury. Pathophysiology and Prospective Therapeutic Targets]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Winkler]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Minter]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Yue]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Manley]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Neurosurg Clin N Am]]></source>
<year>2016</year>
<volume>27</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>473-88</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Traumatic Brain Injury Advances]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stein]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Feather]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Napolitano]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Clin]]></source>
<year>2017</year>
<volume>33</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-13.</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hypertonic saline infusion for treating intracranial hypertension after severe traumatic brain injury]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mangat]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Lond Engl]]></source>
<year>2018</year>
<volume>22</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>37</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Incidence and prognosis of dysnatremias present on ICU admission]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Funk]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lindner]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Druml]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[Intensive Care Med]]></source>
<year>2010</year>
<volume>36</volume>
<page-range>304-11</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Intesive care unit-aacquired hypernatremia is an independent predictor of increased mortality and lenght of stay]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Waite]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fuhrman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Badawi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Zuckerman]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Franey]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Critical Care]]></source>
<year>2013</year>
<volume>28</volume>
<page-range>405-12</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The relationship between serum sodium and intracranial pressure when using hypertonic saline to target mild hypernatremia in patients with head trauma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wells]]></surname>
<given-names><![CDATA[DL]]></given-names>
</name>
<name>
<surname><![CDATA[Swanson]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Wood]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[Magnotti]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Boucher]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[Croce]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care Lond Engl]]></source>
<year>2012</year>
<volume>16</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>R193</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effect of Hypernatremia on Outcomes After severe Traumatic Brain Injury: A Nationwide Inpatient Sample análisis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hoffman]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Jalal]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Chin]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<source><![CDATA[World Neurosurg]]></source>
<year>2018</year>
<page-range>e1-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A Nationwide Study of Incidence and Mortality Due to Traumatic Brain Injury in Ecuador (2004-2016).]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ortiz-Prado]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Mascialino]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Paz]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez-Lorenzana]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez-Barreno]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Simbaña-Rivera]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Neuroepidemiology]]></source>
<year>2020</year>
<volume>54</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>33-44</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Predictors of Hospital Mortality and the Related Burden of Disease in Severe Traumatic Brain Injury: A Prospective Multicentric Study in Brazil]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Areas]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Schwarzbold]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Diaz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Front. Neurol]]></source>
<year>2019</year>
<volume>10</volume>
<numero>43</numero>
<issue>43</issue>
<page-range>1-8</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[New prehospital scoring system for traumatic brain injury to predict mortality and severe disability using motor Glasgow Coma Scale, hypotension, and hypoxia: a nationwide observational study.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hong]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Shin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Ro]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Clin Exp Emerg Med]]></source>
<year>2019</year>
<volume>6</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>152-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Morbidity and mortality associated with hypernatremia in patients with severe traumatic brain injury]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vedantam]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Robertson]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gopinath]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Neurosurg Focus]]></source>
<year>2017</year>
<volume>43</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1-5</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hypernatremia severity and the risk of death after traumatic brain injury]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Injury]]></source>
<year>2012</year>
<volume>44</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1213-8</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The effect of continuous hypertonic saline infusion and hypernatremia on mortality in patients with severe traumatic brain injury: a retrospective cohort study.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kolmodin]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Sekhon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Qiao]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zou]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Henderson]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[J Can Anesth]]></source>
<year>2016</year>
<volume>63</volume>
</nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comparative study of computed tomographic scoring systems and predictors of early mortality in severe traumatic brain injury.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pargaonkar]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Menon]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hegde]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Clinical Neuroscience]]></source>
<year>2019</year>
<volume>66</volume>
<page-range>100-6</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Hypernatremia in the neurologic intensive care unit: how high is too high?.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aiyagari]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Deibert]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Diringer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Crit Care]]></source>
<year>2006</year>
<volume>21</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>163-72</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The relation between the incidence of hypernatremia and mortality in patients with severe traumatic brain injury]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maggiore]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Picetti]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Antonucci]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Parenti]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Regolisti]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Mergoni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Crit Care]]></source>
<year>2009</year>
<volume>13</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Traumatic brain injury: intensive care management]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Helmy]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vizcaychipi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Br J Anaesth]]></source>
<year>2007</year>
<volume>99</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>32-42</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Acute diabetes insipidus in severe head injury: a prospective study.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hadjizacharia]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Beale]]></surname>
<given-names><![CDATA[EO]]></given-names>
</name>
<name>
<surname><![CDATA[Inaba]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[LS]]></given-names>
</name>
<name>
<surname><![CDATA[Demetriades]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[J Am Coll Surg]]></source>
<year>2008</year>
<volume>207</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>477-84</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Diabetes insipidus after traumatic brain injury]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Capatina]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Paluzzi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mitchell]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Karavitaki]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Med]]></source>
<year>2015</year>
<volume>4</volume>
<page-range>1448-62</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
