<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2631-2581</journal-id>
<journal-title><![CDATA[Revista Ecuatoriana de Neurología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ecuat Neurol]]></abbrev-journal-title>
<issn>2631-2581</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica Ecuatoriana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2631-25812021000100200</article-id>
<article-id pub-id-type="doi">10.46997/revecuatneurol30100200</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome De Persona Rígida De Causa Paraneoplásica. Claves Diagnosticas En Una Entidad Rara]]></article-title>
<article-title xml:lang="en"><![CDATA[Stiff Person Syndrome Of Paraneoplastic Cause. Diagnostic Keys In A Rare Entity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Burbano]]></surname>
<given-names><![CDATA[Braulio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro-Uquillas]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Núñez]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Especialidades Carlos Andrade Marín Departamento de Neurología ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Metropolitano Departamento de Neurología ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital de Especialidades Carlos Andrade Marín Departamento de Medicina Nuclear ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>07</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>07</month>
<year>2021</year>
</pub-date>
<volume>30</volume>
<numero>1</numero>
<fpage>200</fpage>
<lpage>205</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&amp;pid=S2631-25812021000100200&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&amp;pid=S2631-25812021000100200&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_pdf&amp;pid=S2631-25812021000100200&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Los desórdenes paraneoplásicos ejercen su efecto a través de mecanismos inmunológicos y no por invasión directa del tumor; de esta manera los tumores localizados fuera del sistema nervioso inducen la producción de anticuerpos contra antígenos: de la superficie neuronal, intracelulares o sinápticos y afectan sitios distantes de su ubicación ya sea al sistema nervioso central como al periférico produciendo de esta forma diversas manifestaciones clínicas. Uno de estos síndromes es el de Persona Rígida que, aparte de ser una entidad rara, ocurre como un síndrome paraneoplásico apenas en el 5% de casos.  Caso Clínico:  Hombre de 72 años con cuadro de 2 meses de evolución que inició con espasmos musculares dolorosos en la región dorsal y lumbar, evolucionando a rigidez con postura en hiperextensión axial y apendicular, marcha pseudoespástica, hiperekplexia; ante la sospecha de síndrome de Persona Rígida se inició el trabajo diagnóstico y se encontraron niveles elevados de Ac anti GAD65 y posteriormente un Linfoma No Hodgkin. Recibió inmunoterapia y tratamiento oncológico.  Conclusión:  Los síndromes paraneoplásicos deben ser identificados según el fenotipo clínico y la determinación de anticuerpos antineuronales. La alta sospecha y el diagnóstico rápido son necesarios para lograr un tratamiento oportuno y evitar injuria permanente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Paraneoplastic disorders exert their effect through immunological mechanisms and not by direct invasion of the tumor; in this way tumors located outside the nervous system induce the production of antibodies against antigens: on the neuronal surface, intracellular or synaptic and affect distant sites from its location to either the central or peripheral nervous system, thus producing various clinical manifestations. One of these syndromes is the Stiff Person syndrome, which, apart from being a rare entity, occurs as a paraneoplastic syndrome in only 5% of cases.  Clinical Case:  A 72-year-old male patient, a 2-month evolution that began with painful muscle spasms in the dorsal and lumbar region, evolved to rigidity with posture in axial and appendicular hyperextension, pseudospastic gait, hyperekplexia; due to the suspicion of Stiff Person syndrome a diagnostic work-up was begun finding high levels of Ab anti GAD65 and later a Non-Hodgkin's Lymphoma. The patient received immunotherapy and cancer treatment.  Conclusion:  Paraneoplastic syndromes must be identified according to the clinical phenotype and the determination of antineuronal antibodies. High suspicion and rapid diagnosis are necessary to achieve timely treatment and avoid permanent injury.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Anticuerpos antineuronales]]></kwd>
<kwd lng="es"><![CDATA[desórdenes paraneoplásicos]]></kwd>
<kwd lng="es"><![CDATA[síndrome de Persona Rígida]]></kwd>
<kwd lng="es"><![CDATA[linfoma No Hodgkin.]]></kwd>
<kwd lng="en"><![CDATA[Antineuronal antibodies]]></kwd>
<kwd lng="en"><![CDATA[paraneoplastic disorders]]></kwd>
<kwd lng="en"><![CDATA[stiff-person syndrome]]></kwd>
<kwd lng="en"><![CDATA[Non-Hodgkin lymphoma]]></kwd>
</kwd-group>
</article-meta>
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