<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2631-2581</journal-id>
<journal-title><![CDATA[Revista Ecuatoriana de Neurología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ecuat Neurol]]></abbrev-journal-title>
<issn>2631-2581</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica Ecuatoriana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2631-25812019000100032</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Fibrinólisis Farmacológica En El Ictus Isquémico Agudo. Experiencia En Un Hospital Terciario Del Ecuador]]></article-title>
<article-title xml:lang="en"><![CDATA[Pharmacological Thrombolysis In Ischemic Stroke. Experience In A Tertiary Hospital From Ecuador]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Scherle Matamoros]]></surname>
<given-names><![CDATA[Claudio Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivero Rodríguez]]></surname>
<given-names><![CDATA[Dannys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Di Capua Sacoto]]></surname>
<given-names><![CDATA[Daniella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maldonado Samaniego]]></surname>
<given-names><![CDATA[Nelson]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mullo Almache]]></surname>
<given-names><![CDATA[Elena de los Ángeles]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santacruz Villalba]]></surname>
<given-names><![CDATA[María José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nuñez Cabezas]]></surname>
<given-names><![CDATA[Verónica Alexandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tohme Sussmann]]></surname>
<given-names><![CDATA[Felipe Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad San Francisco de Quito  ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Especialidades Eugenio Espejo Servicio de Neurología ]]></institution>
<addr-line><![CDATA[Quito ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>28</volume>
<numero>1</numero>
<fpage>32</fpage>
<lpage>38</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&amp;pid=S2631-25812019000100032&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&amp;pid=S2631-25812019000100032&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.senescyt.gob.ec/scielo.php?script=sci_pdf&amp;pid=S2631-25812019000100032&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La trombolisis farmacológica en el ictus isquémico se asocia a una mejor recuperación.  Objetivo: Describir los resultados del tratamiento con r-Tpa regido por un protocolo y código ictus intrahospitalario durante un año de trabajo.  Métodos:  Se realizó un estudio prospectivo, longitudinal en pacientes con infarto cerebral ingresados en la Unidad de ictus, con seguimiento clínico hasta 3 meses después del alta hospitalaria. Las variables evaluadas se compararon entre dos grupos de pacientes, tratados o no.  Resultados:  Se estudiaron 107 pacientes: 16 (14,9 %) fueron trombolizados, 29 (27,1%) arribaron en periodo de ventana terapéutica y 76 (71%) llegaron después de las 4.5 horas. La edad promedio fue de 68,8 años y predominaron las mujeres. El mayor impacto de la trombolisis fue sobre la diferencia de puntaje entre la evaluación inicial y al alta en la escala del NIHSS. A los tres meses de evolución, el porcentaje de pacientes con discapacidad leve (Rankin 0-2) casi se igualó en los dos grupos. La mortalidad se incrementó a expensas de los pacientes con discapacidad más severa (Rankin 3-5).  Conclusiones:  El tratamiento con r-Tpa demuestra beneficios al alta hospitalaria. Se requiere de análisis posterior con mayor número de casos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Pharmacological thrombolysis in ischemic stroke is associated with a better recovery.  Objective:  Describe the thrombolysis results after using r-Tpa applying an intrahospital stroke code, during one year.  Methods:  A prospective, longitudinal study was performed in patients with cerebral infarction admitted to the stroke unit, with clinical follow-up up to 3 months after hospital discharge. The variables evaluated were compared in two groups of patients (only one group received the treatment).  Results:  107 patients were studied: 16 (14.9%) were thrombolyzed, 29 (27.1%) arrived in the therapeutic window period and 76 (71%) arrived after 4.5 hours. The average age was 68, 8 years and women predominated. The greatest impact of thrombolysis was on the difference in score between the initial assessment and the discharge on the NIHSS scale. At three months of evolution, the percentage of patients with mild disability (Rankin 0-2) was almost equal in the two groups. Mortality increased in patients with more severe disability (Rankin 3-5).  Conclusions:  Treatment with r-Tpa shows benefits at hospital discharge. Further analysis is required with a greater number of cases.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Accidente cerebrovascular]]></kwd>
<kwd lng="es"><![CDATA[Infarto cerebral]]></kwd>
<kwd lng="es"><![CDATA[Terapia trombolítica]]></kwd>
<kwd lng="es"><![CDATA[Fibrinólisis]]></kwd>
<kwd lng="es"><![CDATA[Ecuador.]]></kwd>
<kwd lng="en"><![CDATA[Stroke. Cerebral infarction]]></kwd>
<kwd lng="en"><![CDATA[Thrombolytic therapy]]></kwd>
<kwd lng="en"><![CDATA[fibrinolysis]]></kwd>
<kwd lng="en"><![CDATA[Ecuador.]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA[Intravenous Recombinant Tissue Plasminogen Activator Does Not Impact Mortality in Acute Ischemic Stroke at Any Time Point up to 6 Months: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Uhrig]]></surname>
<given-names><![CDATA[D]]></given-names>
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<name>
<surname><![CDATA[Fowler]]></surname>
<given-names><![CDATA[S]]></given-names>
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<name>
<surname><![CDATA[DeLaney]]></surname>
<given-names><![CDATA[MC]]></given-names>
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<name>
<surname><![CDATA[Alexandrov]]></surname>
<given-names><![CDATA[AV]]></given-names>
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<source><![CDATA[CNS Drugs]]></source>
<year>2015</year>
<volume>29</volume>
<page-range>659-67</page-range></nlm-citation>
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