Abstract

QUIMI LOPEZ, Dennis Ignacio; QUINTERO SANCHEZ, Ruth; VELEZ DIAZ, Eva  and  ACUNA ZHINGRI, Nancy María. Tuberculosis resistente a medicamentos de primera línea en pacientes del cantón Durán, Ecuador. Rev Eug Esp [online]. 2022, vol.16, n.1, pp.81-89. ISSN 2661-6742.  https://doi.org/10.37135/ee.04.13.09.

Tuberculosis is a disease that continues to be a public health problem. In this regard, a non-experimental cross-sectional study was carried out to characterize clinically and epidemiologically the status of TB resistant to first-line drugs in the city of Durán, from January 2015 to December 2019. The data included in the resistant tuberculosis program matrix documents. 1111 new cases of tuberculosis were reported in the Duran canton during the study period, 45 of these ones presented resistance to first-line drugs. 88.89% had rifampicin resistance, 33.33% of the patients were dispensed in 2019. Pearson's chi-square values did not show a statistically significant association between the investigated variables (p> 0.05). Among the study population, it was predominated the age group between 20 and 39, male sex, pulmonary tuberculosis, infected with HIV / AIDS, resistance classified as primary, those who abandoned the follow-up to treatment and the non-manifestation of adverse drug reactions. No mortality was observed among new cases, predominantly among those ones with relapse, the male gender and those ones who had extrapulmonary tuberculosis.

Keywords : Epidemiologic Factors; Tuberculosis; Drug Resistance.

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