Introduction:

Acute lymphoblastic leukemia (ALL) is a malignant neoplasm characterized by the proliferation of abnormal lymphoid cells in bone marrow (BM) and/or extramedullary territories.

Case report:

20-year-old male with BCR-ABL B-ALL in childhood, presenting with subacute flaccid paraparesis (PFS) and paresthesias in the lower limbs. He presents with motor axonal polyneuropathy, leptomeningeal uptake in left occipito-parietal sulci and extramedullary intrathecal D11-S1 infiltration. Immunoblasts in peripheral blood and MO with BCR-ABLp190 mutation confirm late relapse of ALL.

Conclusions:

We expose a rare case of PFS and carcinomatous meningitis as a form of presentation of late relapse of BCR-ABL ALL-B BCR-ABL.

Progressive subacute flaccid paraparesis flaccida and subclinical carcinomatous meningitis as a presentation of late relapse of BCR-ABL/Phi+ B-lymphoblastic acute lymphoblastic leukaemia.