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Revista Ecuatoriana de Neurología

versión On-line ISSN 2631-2581versión impresa ISSN 1019-8113


CASALLAS-VANEGAS, Adriana et al. CLIPPERS (Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement And Steroid Response) With Longitudinally Extensive Spinal Cord Involvement. An Atypical Presentation. Rev Ecuat Neurol [online]. 2022, vol.31, n.2, pp.110-114. ISSN 2631-2581.

CLIPPERS (Chronic Lymphocytic Inflammation with Perivascular Pontine Enhancement and Steroid Response) is a recently described neuroinflammatory disorder in which symptoms involving the brainstem predominate, with variable pattern on neuroimaging and a perivascular infiltrate of T lymphocytes on brain biopsy. We present a case of a 50-year-old male who presented symptoms of asthenia, adynamia, weakness in lower limbs extremities, sphincter disorder and ataxia. Patient was extensively studied to rule out infectious, neoplastic, autoimmune, and demyelinating conditions. Diagnosis was made taking into account significant clinical-imaging elements, remarking the spinal cord involvement in this patient. Treatment with steroids and steroid-sparing agents, such as methotrexate, was found to be effective. Very few cases in the literature to date describe CLIPPERS-associated spinal cord involvement.

Palabras clave : CLIPPERS; ataxia; brainstem; spinal cord; methotrexate (MeSH).

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