SciELO - Scientific Electronic Library Online

 
vol.30 número1Las variaciones étnicas todavía están infrarrepresentadas en la neuro Farmacogenómica: una revisión sistemáticaParálisis cerebral en pediatría: problemas asociados. índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Ecuatoriana de Neurología

versión On-line ISSN 2631-2581versión impresa ISSN 1019-8113

Resumen

HENAO-ARBOLEDA, Eiana  y  PINEDA, David. Episodic memory in the preclinical stages of genetic Alzheimer´s disease. Rev Ecuat Neurol [online]. 2021, vol.30, n.1, pp.104-114. ISSN 2631-2581.  https://doi.org/10.46997/revecuatneurol30100104.

Introduction:

Episodic memory (EM) allows us to recall events or lived experiences. EM is associated to the medial temporal lobe (MTL) activity, which has circuits integrated by different cortical association areas. EM impairment is the first symptom of Alzheimer's disease (AD), which is explained by the abnormal beta amyloid (βA) and phosphorylated tau protein (PTF) deposition in the MTL.

Development:

A review about EM components and its assessment is done, especially related to preclinical stages of genetic AD. The relationship of EM components to βA and TFP deposition and the activity of MTL networks, using positron emission tomography (PET) of the brain, particularly in asymptomatic members of families at genetic risk for early AD, caused by the E280A mutation in preseniline 1 (PSN1), is revised.

Conclusions:

The reviewed studies trend to validate the hypothesis, which would suggest that EM allows us to consolidate and recalling lived subjective experiences, which also allows us learning from the past. EM has been assessed with verbal declarative memory tasks. The asymptomatic members, carrying the E280A PSN1 mutation for genetic AD, have showed lower scores than asymptomatic non carriers on these memory tasks, which significantly correlates to PET-amyloid and PET-tau of MTL signals, up to 20 years before dementia onset.

Palabras clave : Episodic Memory; Alzheimer´s Disease; Medial Temporal Lobe; Hippocampus..

        · resumen en Español     · texto en Español     · Español ( pdf )