SciELO - Scientific Electronic Library Online

vol.28 issue3Facial Palsy Secondary To Arteritis Of The Internal Carotid Artery In A School PatientSchwannoma With A Non-Frequent Location In Pediatric Patient. Case Report author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Revista Ecuatoriana de Neurología

On-line version ISSN 2631-2581Print version ISSN 1019-8113


GUTIERREZ-BAQUERO, Julian; DURAN-AYLLON, Juan Pablo  and  SILVA-SOLER, Miguel. Rapidly Progressive Dementia As A Manifestation Of Relapse In Mantle Cell Lymphoma: Experience In Diagnosis And Treatment. Rev Ecuat Neurol [online]. 2019, vol.28, n.3, pp.98-100. ISSN 2631-2581.


Rapidly progressive dementia is an entity that has a multiple and heterogeneous etiology. It is characterized by the alteration of two or more cognitive domains in a period of less than 1 to 2 years. The involvement of the central nervous system attributed to mantle cell lymphoma is rare with a poor prognosis and mainly debuts in the late stages of the disease as a relapse.

Case Report:

A 61-year-old male with a history of mantle cell lymphoma who presents a relapse of the central nervous system, given by a clinical course compatible with a rapidly progressive dementia and which is confirmed by flow cytometry studies in cerebrospinal fluid. It presents an adequate response to management with a tyrosine kinase inhibitor (Ibrutinib), resolving clinical symptoms and imaging findings.


The involvement of the central nervous system secondary to mantle cell lymphoma is a rare complication and debuts as a relapse with variable clinical manifestations that requires a timely intervention with the aim of improving patient survival. Therapy with a single agent such as Ibrutinib seems to be a good alternative in cases of refractoriness and neurological involvement.

Keywords : dementia; mantle cell lymphoma; magnetic resonance imaging; B-lymphocytes.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )