SciELO - Scientific Electronic Library Online

vol.27 número2Fístula Carótido Cavernosa. Utilidad del ultrasonido Doppler en el diagnóstico. índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • No hay articulos similaresSimilares en SciELO


Revista Ecuatoriana de Neurología

versión On-line ISSN 2631-2581versión impresa ISSN 1019-8113


ALVAREZ-DUQUE, Martha Elena et al. Symptomatology heterogeneity. Profiles of patients diagnosed with Alzheimer's type dementia in Antioquia (Colombia). Rev Ecuat Neurol [online]. 2018, vol.27, n.2, pp.11-19. ISSN 2631-2581.


To describe and contrast the symptomatic variability of cases with sporadic or non-sporadic Alzheimer's dementia (DTA + E) with the data obtained from the cases with early familial Alzheimer's dementia caused by the E280A of the Neurobank of the Neurosciences Group of Antioquia (GNA).

Materials and Method:

This study was of exploratory - descriptive and correlacional type, 83 donors' cases were taken with DTA stored in the Neurobank. These cases were divided in two groups, i) a group defined genetically like E280A; and ii) another not carrying group of the mutation (DTA+E); the scoreboards and / or characteristics neuropsychiatric, neuropsychological, neurological and neuropathological of both groups were confirmed


The symptom that showed higher differences between both groups was iteration (DTAF E280A with 1.2% and 18.4% for the DTA+E group). Other symptoms as depression or the time of appearance of progressive loss of memory did not show big differences among groups (DTAF E2080A=55.9%; DTA+E =53.1%) and (DTAF E2080A=55.9%; DTA+E =53.1%). The language disorders that were observed with major frequency among the donors were the loss of the language, mutism, anomia and aphasia. The sign with higher frequency in both groups was lost of sphincter control. The atrophy was with more intensity in the temporary lobes of the brains of the donors with DTA+E (83.3%). The weight of the brain and of the posterior fosse content, they have a moderate, directly proportional and highly significant relation from the statistical point of view.


DTA +E has neuropathological differences with DTAF E280A that can be associated with the physiology hereditary from of DTAF E280A.

Palabras clave : Dementia; Alzheimer.

        · resumen en Español     · texto en Español     · Español ( pdf )