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Revista Ecuatoriana de Neurología
versão On-line ISSN 2631-2581versão impressa ISSN 1019-8113
Resumo
BURGOS, Bernardo; CIGARROA, Igor e TOLOZA-RAMIREZ, David. Effectiveness And Safety Profile Of Oral Cannabis Preparations For The Treatment Of Refractory Epilepsies In Infant-Young Population: A Scoping Review. Rev Ecuat Neurol [online]. 2023, vol.32, n.1, pp.62-74. ISSN 2631-2581. https://doi.org/10.46997/revecuatneurol32100062.
Introduction:
Refractory epilepsies (RE) are a common neurological condition expressed in childhood and adulthood, highlighting the current use of cannabis as an alternative treatment. Oral Cannabis Preparations (OCP) have demonstrated effectiveness in the adult population; however, knowledge is limited in the infant-young population.
Aim:
To synthesize the available evidence on the efficacy and safety of OCP for the treatment of refractory epilepsies in the infant-young population.
Methods:
The present study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines and included studies from January 2013 until December 2020 from electronic databases, including SciELO, ScienceDirect, PubMed, and Web of Science.
Results:
7 articles were included in this scoping review for critical analysis. The results indicate that pharmaceutical and artisanal origin OCP has 41.3% effectiveness in reducing seizures and low safety after administration (≤ 27.4%). Likewise, after administration, the most frequent adverse symptoms were somnolence/fatigue, weight loss/decreased appetite, and irritability/aggressiveness.
Conclusion:
The low levels of effectiveness and safety of OCP suggest that they should be administered with caution and as a complementary treatment and not as the first choice for managing RE in the infant-young population.
Palavras-chave : Cannabis; Cannabidiol; Refractory Epilepsy; Seizures; Scoping Review..