32 1 
Home Page  

  • SciELO

  • SciELO


Revista Ecuatoriana de Neurología

 ISSN 2631-2581 ISSN 1019-8113

BURGOS, Bernardo; CIGARROA, Igor    TOLOZA-RAMIREZ, David. Effectiveness And Safety Profile Of Oral Cannabis Preparations For The Treatment Of Refractory Epilepsies In Infant-Young Population: A Scoping Review. []. , 32, 1, pp.62-74. ISSN 2631-2581.  https://doi.org/10.46997/revecuatneurol32100062.

Introduction:

Refractory epilepsies (RE) are a common neurological condition expressed in childhood and adulthood, highlighting the current use of cannabis as an alternative treatment. Oral Cannabis Preparations (OCP) have demonstrated effectiveness in the adult population; however, knowledge is limited in the infant-young population.

Aim:

To synthesize the available evidence on the efficacy and safety of OCP for the treatment of refractory epilepsies in the infant-young population.

Methods:

The present study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines and included studies from January 2013 until December 2020 from electronic databases, including SciELO, ScienceDirect, PubMed, and Web of Science.

Results:

7 articles were included in this scoping review for critical analysis. The results indicate that pharmaceutical and artisanal origin OCP has 41.3% effectiveness in reducing seizures and low safety after administration (≤ 27.4%). Likewise, after administration, the most frequent adverse symptoms were somnolence/fatigue, weight loss/decreased appetite, and irritability/aggressiveness.

Conclusion:

The low levels of effectiveness and safety of OCP suggest that they should be administered with caution and as a complementary treatment and not as the first choice for managing RE in the infant-young population.

: Cannabis; Cannabidiol; Refractory Epilepsy; Seizures; Scoping Review..

        · |     · |     · ( pdf )